Call for Diabetes Research Proposals

*Please note that the GACD diabetes call is now closed.*

Diabetes Call Small


Photo by GACD researcher Dr Rajesh Vedanthan

The GACD has  launched its second call for research proposals . So, why are GACD Member Agencies going to fund research on diabetes? Watch the video here on what GACD Board Members expect from the call.

Please see the following call outline for further information and details on how to apply. Please note, GACD members will be publishing the call on their websites within the coming months and deadlines will be announced here as and when they are released.

In the past twenty years the global death rate from diabetes has doubled (1) and the World Health Organization (WHO) is predicting that this will increase by two thirds by 2030. It is currently estimated that 347 million people worldwide suffer from diabetes, with more than 80% living in low- and middle-income countries. Of those suffering from diabetes, type 2 comprises 90% of this population around the world (2). Halting the rise in prevalence of diabetes has been identified as one of the 9 WHO NCD global voluntary targets to be met by Member States by 2025.

With the burden of this chronic non-communicable disease ever-increasing the Global Alliance for Chronic Diseases (GACD) has agreed to launch a call for proposals on the prevention and treatment of type 2 diabetes, with a focus on implementation and intervention research in low- and middle-income countries, and indigenous populations in Canada and Australia. The emphasis of this initiative is on existing approaches to prevention and control of type 2 diabetes rather than development of new treatments.

In order to maximise the impact of the joint call, research teams applying for funding are expected to consist of researchers from low- and middle-income countries and high-income countries.

If you would like to form a potential partnership with researchers or institutions that are based in our Funding Agencies' countries, please join our professional forum on LinkedIn to get in touch with other researchers around the world. 

To watch an information webinar held by the Canadian Institutes of Health Research  on the type 2 diabetes funding opportunity please click here.

Call for diabetes research proposals

Call focus: implementation science research

Regional focus: Low- and middle-income countries, vulnerable populations and indigenous populations in Canada and Australia.

In the past twenty years the global death rate from diabetes has doubled (1) and the World Health Organization (WHO) is predicting that this will increase by two thirds by 2030. It is currently estimated that 347 million people worldwide suffer from diabetes, with more than 80% living in low- and middle-income countries. Of those suffering from diabetes, type 2 comprises 90% of this population around the world (2). Halting the rise in prevalence of diabetes has been identified as one of the 9 WHO NCD global voluntary targets to be met by Member States by 2025.

With the burden of this chronic non-communicable disease ever-increasing the Global Alliance for Chronic Diseases (GACD) has agreed to launch a call for proposals on the prevention and treatment of type 2 diabetes, with a focus on implementation and intervention research in low- and middle-income countries, and indigenous populations in Canada and Australia. The emphasis of this initiative is on existing approaches to prevention and control of type 2 diabetes rather than development of new treatments.

(1) Lozano et al; The Lancet, Dec 2012, Vol 380, Issue 9859

(2) http://www.who.int/mediacentre/factsheets/fs312/en/index.html

Aim

The aim of this call is to fund projects that will generate new knowledge on interventions and their implementation for the prevention and treatment of type 2 diabetes in low- and middle-income countries (LMIC), as defined by The World Bank, and additionally:

  1. Applications to CIHR can include work with Aboriginal, First National, Inuit and Métis Vulnerable populations
  2. Applications to the NHMRC can address type 2 diabetes in Aboriginal and Torres Strait Islander populations.

(For details on eligibility criteria please check with each respective funding body.)

The GACD partnership is therefore looking for projects that focus on the guiding principles of:

  • Reducing health inequalities and inequities in the prevention and treatment of type 2 diabetes in both a local and global context.
  • Pursuing knowledge translation and exchange approaches that are designed to maximize the public health benefits of research findings within different health contexts.
  • Providing evidence to inform local health service providers, policy and decision makers on the effective scaling up of the interventions at the local, national and regional level.

Through the launch of a global call the GACD aims to develop a global network of researchers that can enhance the cumulative learning across the individual projects, and work towards understanding how socio-economic, cultural, geopolitical and policy contexts have influenced results and how findings might be adapted and applied in different settings. The funded researchers will form part of a Joint Technical Steering Committee which will meet annually to discuss their research and share information in order to develop approaches to standardise data collection, and wherever feasible to use these standardised approaches in their respective projects.

Scope

Researchers responding to this call can focus on a wide range of prevention and/or treatment strategies. This might include programmes addressing (one or combinations of):

  • Lifestyle and behavioural issues such as what changes can be made to provide an environment that supports and promotes better health. This might include community-wide approaches, or other strategies targeting individuals at high-risk. For instance, population prevention strategies designed to address unhealthy diets and physical inactivity as risk factors for diabetes.
  • Structural interventions or policies designed to promote improved health outcomes. For instance, evaluating the contribution of public policies to diabetes prevention efforts, or monitoring the potential effects of such policies if adopted and implemented.
  • Delivery of relevant health care and health interventions.
  • Approaches to implementing accessibility of or adherence to, pharmaceutical, nutritional or other promising or proven interventions.

Researchers with ideas that do not fall within these categories are encouraged to contact their relevant funding agency to discuss whether their research idea fits the aims and scope of the call.

This call is focused on implementation research, to examine what works, for whom and under what contextual circumstances, and how interventions can be adapted and scaled up in ways that are accessible and equitable.

Proposals can address prevention or treatment of specific complications of type 2 diabetes. Applicants must justify clearly in their proposal why their chosen topic fits within the aims and scope of this call.

Projects addressing gestational diabetes are within the scope of this call.

Projects can focus on specific societal groups but a clear justification should be provided as to why the group has been chosen and how the choice will assist the funders in delivering their aim to address health inequities at a local and/or global level.

This call is focused on implementation research into interventions for prevention and treatment of type 2 diabetes that are applicable in low resource settings. However, in some settings, the project may need to incorporate work to establish baseline data on prevalence of diabetes and its risk factors to evaluate the impact of the intervention. Research into these aspects can be incorporated into the proposed work if it does not duplicate existing evidence available.

The following types of projects DO NOT fall within the scope of this call:

  • Replication of effectiveness studies and clinical trials testing the efficacy or effectiveness of new or established pharmacological agents (or combination of agents) which have wider effects than those relating to type 2 diabetes.
  • Aetiological work, mechanistic, or epidemiological research, which is not part of a wider study to develop implementation science approaches.
  • Phase I or Phase IIa trials.

Assessment Criteria

Applications for grants will be assessed against the following criteria:

  • Relevance and Quality of Project
  • Quality of Team
  • Project Implementation Plans
  • Potential Impact

Criterion One: Relevance and Quality of Project

  1. Proposal fits well within the objectives and scientific remit set out in the call.
  2. Strong scientific rationale for pursuing the questions or gaps in knowledge that are being addressed. Success is likely to lead to significant new understanding that is relevant for scientists and knowledge users. Applicants are aware of complementary research underway elsewhere.
  3. Proposed methods are appropriate and feasible to answer the study question(s) and are considered best in the international field of implementation science research (e.g. mixed methods designs, in-depth comparative case studies, pragmatic cluster RCTs, natural experiments).
  4. Proposal is innovative (applicants may want to refer to the document on integrated innovation - http://www.grandchallenges.ca/files/news/integratedInnovation.pdf)
  5. Intervention has been adequately described.

Criterion Two: Quality of Team

  1. Multidisciplinary team members have established a high quality track record in related fields of proposed research and pertinent to implementation science and they have the right balance of expertise given goal(s) of research project.
  2. Each country participating in the project must have a named principal investigator.
  3. Early career investigators are part of the team and strong training plan for research capacity-building is included.
  4. Demonstrated engagement of decision-makers.

Criterion Three: Project Implementation Plans

  1. Major scientific, technical or organisational challenges been identified, and realistic plans to tackle these are outlined.
  2. Proposed intervention strategies are relevant to the socio-political, cultural, legislative and economic contexts of the study settings.
  3. Inequities and equity gaps including gender have been taken into account in the design of an implementation strategy.
  4. Objective measures of evaluation have been included. Programmes that are able to track long-term clinical, policy and/or health system outcomes are strongly encouraged.

Criterion Four: Potential Impact

  1. Project demonstrates alignment with international and/or national commitments to halt the rise in prevalence of type 2 diabetes.
  2. Project appropriately leverages existing programmes and platforms (e.g. research, data, delivery platforms)
  3. The potential for scaling up intervention strategies has been considered. For example, applicants could address affordability for users and the financial implications for implementing organisations and funders or might assess scalability to various socio-political contexts.
  4. Projects are designed to inform practice, programmes and/or policy development and/or refinements.
  5. Describe how health economic dimensions will be assessed such as cost-effectiveness of proposed intervention and its scalability.

All applications must describe:

  • System barriers (health care and other) to treatment and prevention of type 2 diabetes and how these can be addressed
  • System facilitators and how these will be leveraged
  • How decision-makers and other knowledge users will be engaged in the project
  • An implementation research component - implementation should involve some strategies with demonstrated efficacy and/or effectiveness and may also include the development of new strategies
  • An assessment of equity and gender gaps and the needs of vulnerable populations** in treatment and prevention of type 2 diabetes
  • The multidisciplinary composition of research teams
  • An appropriate plan for knowledge translation and exchange as a component of the project
  • Training plan for research capacity building

Note: ** see description of vulnerable populations for each funding council

All funded projects must comply with appropriate local and national regulatory and ethical requirements. Projects which include work in India must indicate understanding of the amended clinical trials regulations in India, and how they will incorporate those requirements into their project design and management.

Background

This request for applications is issued under the auspices of the Global Alliance for Chronic Diseases (GACD). Members of the GACD include the:

  • Australian National Health and Medical Research Council
  • Canadian Institutes of Health Research
  • Chinese Academy of Medical Sciences
  • Research & Innovation Directorate General of the European Commission
  • Indian Council of Medical Research
  • National Heart, Lung, and Blood Institute, the Fogarty International Center and the National Institute of Mental Health of the National Institutes of Health in the United States of America
  • UK Medical Research Council
  • South African Medical Research Council

The following principles of the GACD are reflected in this request for applications:

  • Committed to improving health gains while reducing health disparities in LMICs.
  • Focused on research topics where the need for evidence to inform policy, programmes and practice is most urgent.
  • Pursuing knowledge translation and exchange approaches that are designed to maximise the public health benefits of research findings.
  • Identifying common approaches for implementation, integration and scaling up within different health service delivery systems.

It is expected that learning from individual projects will provide evidence that will support local decision-making. Cumulative learning across funded projects is expected to provide a basis for evidence-informed recommendations for national and international organisations.

To learn more about the GACD, please visit our website: http://www.gacd.org/

Download the GACD Diabetes Call (PDF).

How to apply

Applications for the GACD type 2 diabetes funding opportunity are welcome from all researchers. The GACD funds research in low-and middle-income countries, vulnerable populations in high-income countries and indigenous populations in Canada and Australia. We welcome partnerships between research institutions.

Applications should be made through individual funding agencies’ websites. You can find tentative application deadlines on this page below. 

National Health and Medical Research Council (Australia) - call published on 31 October 2013

Canadian Institute for Health Research (Canada) - call published on 24 December 2013

Medical Research Council UK (United Kingdom) - call published on 7 November 2013

South African Medical Research Council (South Africa) - call published on 19 November 2013

Indian Council of Medical Research (India) - call published on 15 October 2013

Chinese Academy of Medical Sciences (China)

European Commission (Europe) - call published on 11 December 2013

National Institutes of Health (USA) - call published on 5 December 2013

US-based Investigators are strongly encouraged to contact Dr. Cristina Rabadan-Diehl, in particular those considering work in India, China and/or South Africa, for additional submission criteria.

Cristina Rabadán-Diehl, National Heart, Lung, and Blood Institute

Telephone: +1 301-496-3620, Email: rabadanc@mail.nih.gov

Please refer to each funding agencies’ specific terms and conditions. Each agency has different opening and closing dates for the call. 

For an example of previously funded GACD programmes please click the GACD Projects map.

Please read the FAQs page below before submitting applications.

Application Deadlines

Tentative GACD member agency timelines*

GACD Member Agency
Launch date
Expected deadline for Letters of Intent or outlines
Expected deadline for full proposal
Canadian Institutes of Health Research 24 December 2013 19 February 2014 10 July 2014
Chinese Academy of Medical Sciences January 2014 31 March 2014 July 2014
Indian Council of Medical Research 15 October 2013
28 February 2014 May/June 2014
Medical Research Council (UK) 7 November 2013
11 February 2014 June/July 2014
National Health and Medical Research Council (Australia) 31 October 2013 30 January 2014 2 July 2014
South African Medical Research Council 19 November 2013 End of January 2014
April/May 2014
National Institues of Health (US)
 5 December 2013
30 days prior to the application due date 5 February 2014 (R01) or 16 February 2014 (R03, R21). Please see the 'How to Apply' section for more information on each notice.
European Commission
 11 December 2013
 n/a  15 April 2014

*Please note, these timelines are for guidance only and may be subject to change. Applicants are advised to confirm these dates on the respective funding agencies’ websites.

FAQs

1. How do I apply?

Please refer to the “How to apply” page. Applications are made through funding agencies’ websites, as documented here. Individual agencies have their own specific terms and conditions, so please respond to these. Once the funding agencies have released the call for applications on their website, a direct link and information about the deadlines will be published on the "How to apply" page.

2. Can I apply if I am from a low- or middle-income country?

Yes. GACD members welcome applications and partnership applications that meet the specification of the call. If you are from China, India or South Africa you can apply directly to the GACD member agency in your country, researchers from other LMIC countries should apply as part of a team with researchers from any of the GACD member countries. Please refer to each individual funding agency’s specific terms of reference for further information. Please also refer to the 'Country specific information' for a brief overview.

3. Can I apply if I am from a high-income country?

Yes, you should apply to the GACD member agency in your country or form a partnership with researchers from any of the GACD member countries and apply in the respective country. Most of the GACD member agencies will require you to have partner institutions in at least one other country in order to be eligible for funding. Some agencies are able to fund researchers outside of the GACD member countries. Some agencies are encouraging research involving indigenous or other vulnerable populations. As above please refer to individual funding agencies for further information and take a look at our brief overview of  'Country specific information'.

4. Which Funding Agency should I apply to?

Please refer to the 'Country specific information' for more information. You must apply to one of GACD’s member agencies; the GACD Secretariat will not accept any applications. If you are based in one of the GACD member countries, you should generally apply to the funding agency based in that country.

5. Can I apply to more than one funding agency?

Applicants may not apply to two different agencies with the same project unless they are applying for co-funding. Co-funding applications must be submitted to all applicable funding agencies to their respective deadlines. Please note, deadlines and application processes for all funding agencies may vary considerably and some agencies will require you to submit letters of intent ahead of the full application. Therefore, please confirm application details with each funding agency that you are intending to apply to.  

6. Can I be a named researcher on more than one proposal?

Applicants may be named investigators on more than one proposal if the the proposed projects are independent of each other.

7. Where can my research take place?

In most cases, study sites will be located in low- or middle-income countries, unless the research involves indigenous or vulnerable populations. Some GACD member agencies are able to fund research projects irrespective of whether they will take place in that same member country. Research projects may have study sites in more than one country.

Please note, projects that include research in India are required to also carry out research in a commensurate population, either in the country of the co-funding agency or a third country, as per criterion specified in the agency call. Please note, researchers from India can only receive ICMR funding and no overseas flow of funds is permitted. 

8. Why isn’t there a single application process?

Whilst the GACD members fund joint programmes, each abides by their own funding agency’s individual terms and conditions, deadlines and application procedures.

9. What is the role of the GACD?

The GACD is a unique collaboration of major research funding bodies that seek to address the prevention, control and treatment of chronic non-communicable diseases in low- and middle-income countries as well as indigenous and vulnerable populations in high-income countries. The GACD Secretariat is independent and impartial and facilitates the joint international research.

10. How much funding is being awarded?

Each project is funded in the region of US$ 1-4 million over a period of 3-5 years. Please see our project map or an example of previously funded projects.

11. How is this call for applications unique?

Each research project is conducted through a partnership between investigators from institutions in different countries. The aim is to build upon current research with an emphasis on implementation science. The funded researchers will form a Joint Technical Steering Committee which will meet annually to discuss their research and share information in order to develop approaches to standardise data collection, and wherever feasible to use these standardised approaches in their respective projects.

More information on the Joint Technical Steering Committee.

12. Why isn’t there one opening and closing date for the call?

Each member agency has different opening and closing dates for the call.  A link to each individual agencies' websites will be provided (in the ‘How to Apply’ section) for each agency’s calls for proposals as they are published.

13. Who do I contact if I have any further queries?

Please direct all questions about the GACD Diabetes Call to gacd@ucl.ac.uk. If your query relates to the application process, please contact the respective GACD member agency directly.

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Country specific information

This is an overview of the main eligibility criteria in relation to researchers’ countries of residence. In most cases, if researchers are based in one of the GACD member countries, they should apply for funding from the funding agency in their country. Research teams may include researchers from more than two countries.

Before you submit an application, please always refer to the specific eligibility information as published by each respective funding body.

Which country are you from? *
How can you apply? Who will be funded?                                                                    
Who can you apply to? **
Contact Information 


China

China Flag

  • Researchers from China may either form a partnership with researchers from other GACD member countries and apply jointly OR they may apply as part of a team consisting of Chinese researchers only.                                                   
  • In any case, teams should include researchers affiliated to the Chinese Academy of Medical Sciences as investigators.
  • Teams that are planning to apply jointly for funding from CAMS as well as another GACD member should contact the respective agencies prior to submitting the application.

Chinese Academy of Medical Sciences (CAMS)
Dr Lixin Jiang
lixin.jiang@fwoxford.org


India

India Flag
  • Researchers from India should apply as part of a team that includes investigators from their own country as well as investigators from another GACD member country. Research teams may also include investigators from other countries.
  • Applications should be submitted to the funding bodies in each country. Indian researchers working in India may only be funded by the ICMR and no flow of funds from overseas is allowed. All other investigators should apply for funding from the other GACD member agency.
  • Teams that are planning to apply jointly for funding from ICMR as well as another GACD member should contact the respective agencies prior to submitting the application.
  • Please note that the ICMR requires complementary research to be carried out in the country of the co-funding agency or in a third country, as per criterion specified in the co-funding agency call, in addition to the research proposed in India. Please contact Prashant Mathur for further guidance on this requirement.

Indian Council of Medical Research (ICMR)
Dr Prashant Mathur
mathurp@icmr.org.in


South Africa

South Africa Flag
  • Researchers from South Africa should apply as part of a team that includes investigators from their own country as well as investigators from another GACD member country.
  • Applications should be submitted to the funding bodies in both countries.
  • Teams that are planning to apply jointly for funding from the MRC as well as another GACD member should contact the respective agencies prior to submitting the application.

South African Medical Research Council (MRC)
Dr Johan Louw
johan.louw@mrc.ac.za


Australia

Australian Flag
  • Researchers from Australia should apply as part of a team which include investigators that are based in Australia and one or more low- and middle-income countries.
  • Alternatively, if the research focuses on Australia’s indigenous populations, having international partners is not a requirement. However, research partnerships with investigators from Canada and/or low- and middle-income countries are encouraged for projects focused on indigenous populations.
  • The NHMRC will consider co-funding applications for projects based in China, India or South Africa with the respective local GACD member agency.

National Health and Medical Research Council (NHMRC)
GACD.RFA@nhmrc.gov.au


Canada

Canadian Flag
  • Research teams must include researchers that are based in Canada and low- and middle-income countries.
  • Research with Canada's Aboriginal populations is also eligible and in these cases, having international partners is not a requirement. 
  • Researchers with Canadian Aboriginal populations may also include co-principal investigators or co-investigators from Australia and/or low- and middle-income countries for projects focused on indigenous populations.
  • CIHR will consider co-funding applications for projects based in China, India or South Africa with the respective local GACD member agency.
  • To watch a webinar held by CIHR on the Diabetes Call, please click here.

Canadian Institutes of Health Research (CIHR)
Allison Jackson
allison.jackson@cihr-irsc.gc.ca


UK

UK Flag
  • Researchers from the UK should apply as part of a team which include investigators that are based in the UK and one or more low- and middle-income countries.
  • The MRC will consider co-funding applications for projects based in China, India or South Africa with the respective local GACD member agency as well as co-funding applications for projects based in other low- and middle-income countries with other GACD member agencies.
  • Teams that are planning to apply jointly for funding from the MRC as well as another GACD member should contact the respective agencies prior to submitting the application.

Medical Research Council (MRC)
Jill Jones
jill.jones@headoffice.mrc.ac.uk

European Union

EU Flag
  • Please check the European Commission Diabetes Call web-page here for more information. 
European Commission (EC)
Dr Karim Berkouk
karim.berkouk@ec.europa.eu

USA

United States Flag
  • US-based Investigators are strongly encouraged to contact Dr. Cristina Rabadan-Diehl, in particular those considering work in India, China and/or South Africa for additional submission criteria.

National Insitutes of Health (NIH)
Dr Cristina Rabadan-Diehl rabadanc@mail.nih.gov

Any other country

  • Researchers from any other country not listed above can apply but must do so as part of a team with researchers from any of the GACD member countries and to the funding body in the respective country.

NB

* This means the country you are based in; however, some Funding Agencies have more detailed requirements. Please check with the individual Funding Agencies.

** If your research team consists of investigators in more than one GACD member country, the full application should be submitted to all applicable funding agencies.

*** Please check this web page for more information in the coming weeks.

CIHR, MRC, NHMRC, EC, NIH
 
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Funding Eligibility for GACD Member Agencies

Please see the table below for further information on the funding eligibility for each of the GACD Funding Agencies. 

If you any further enquiries, please contact the individual Funding Agency.

Member agency Countries of origin of investigators eligible for funding Co-PI requirements
CIHR Canada, co-investigators from other GACD member countries excluding India and China, co-investigators from non GACD member countries Co-PI from additional country required unless research involves indigenous population
ICMR India. Principal Investigator must be full time employed in a DSIR (SIRO) recognised institution within India. All Co-investigators must also be from within India Co-PI from additional country required who would receive funding from another GACD member agency
SA MRC South Africa Co-PI from additional country required
NIH US, co-investigators from other GACD member countries excluding India, co-investigators from non GACD member countries Co-PI from additional country required unless research involves vulnerable populations
NHMRC Australia, co-investigators from other GACD member countries excluding India, co-investigators from non GACD member countries Co-PI from additional country required unless research involves indigenous population
EC European Union and associated countries, co-investigators from other countries if their participation is essential Co-PIs from at least three EU countries required
CAMS China Co-PI from additional country not mandatory
MRC UK, co-investigators from other GACD member countries excluding India, co-investigators from non GACD member countries Co-PI from additional country required

Press release

Released 30 August 2013

Members of Global Alliance for Chronic Diseases open call for applications for research into type 2 diabetes.

Photo by GACD researcher Rajesh Vedanthan

rajeshkenya


The GACD is announcing calls for proposals for research into the prevention and treatment of type 2 diabetes, with a focus on implementation and intervention research in low-and middle-income countries, vulnerable populations in high-income countries and indigenous populations in Canada and Australia.

Over the past twenty years, the global death rate from diabetes has doubled (1) and the World Health Organisation (WHO) is predicting that this will increase by two thirds by 2030. It is currently estimated that 347 million people worldwide suffer from diabetes with more than 80% from low- and middle-income countries. Of those suffering from diabetes, type 2 comprises 90% of this population around the world (2).

Through the launch of this global call, the alliance aims to develop a network of researchers that can enhance the cumulative learning across the individual projects, and work towards understanding the findings and how they might be adapted and applied in different settings and scenarios.

We welcome applications for the second GACD joint-funded programme into Type 2 diabetes. The GACD Secretariat is looking forward to its second research programme with a focus on diabetes; these projects will improve the quality of life for millions. We are excited by the prospect of receiving innovative implementation science research proposals that will directly influence global health policy into non communicable-diseases throughout the world.”

Celina Gorre, Executive Director, GACD.

The GACD diabetes call is a groundbreaking research effort of over $22 million of joint funding, which will have a significant impact in the global fight against diabetes.”

Dr Xuetao Cao, Chair Elect, GACD & President Chinese Academy for Medical Sciences.

Click here for full application details.

Read the full press release.

Press Contact: Rosie Bartlett, Communications Manager, GACD - r.bartlett@ucl.ac.uk

References

1. Lozano et al; The Lancet, Dec 2012, Vol 380, Issue 9859

2. http://www.who.int/mediacentre/factsheets/fs312/en/index.html

Find a potential research partner

Most GACD member agencies require their applicants to have research partners, either in another member country or a third country. If you do not have a partnership with researchers or institutions that are based in our Funding Agencies' countries or third countries and would like to form a potential partnership, please be encouraged to join our professional forum on LinkedIn.

Please use this forum to get in touch with other researchers around the world. Join our forum here:

The Global Alliance for Chronic Diseases Professional Forum

(1) Lozano et al; The Lancet, Dec 2012, Vol 380, Issue 9859

(2) http://www.who.int/mediacentre/factsheets/fs312/en/index.html