Leading research collaborations on chronic diseases


Lung Diseases Project - LD05 

EUREST-PLUS: Policy Implementation to Reduce Lung Diseases

Funding organisation

European Commission

Funding amount

$2.6 million


3 years

Project locations

Germany, Greece, Hungary, Poland, Romania, Spain

Principal investigator and coordinating centre

Dr. Constantine Vardavas, European Network for Smoking Prevention



Smoking and other forms of tobacco consumption are considered the single most important cause of preventable morbidity and premature mortality worldwide. Efforts to reduce the devastation of tobacco-related deaths and illness in the EU consist of the Tobacco Products Directive (TPD), and the on-going implementation of the WHO Framework Convention on Tobacco Control (FCTC).

Main objective

The main objective of EUREST-PLUS is to monitor and evaluate the impact of the TPD within the context of FCTC ratification at a European level. These articles in the TPD address issues of tobacco product ingredients, additives, reporting, packaging, labelling, illicit trade, cross border sales, and e-cigarettes.


To achieve the main objective of the project four specific tasks were identified and corresponding methodology defined:

  1. The psychosocial and behavioural impact of TPD implementation will be evaluated through the creation of a cohort study of adult smokers in 6 EU MS (Germany, Greece, Hungary, Poland, Romania, and Spain) in a pre- vs. post- study design.
  2. Support for TPD implementation will be assessed through secondary dataset analyses of the 2015 Special Eurobarometer on Tobacco Survey (SETS), and through trend analyses on the merged datasets of the 2009, 2012 and 2015 SETS datasets.
  3. Changes in e-cigarette product parameters (technical design, labelling, packaging and chemical composition) following implementation of Article 20 of the TPD will be documented.
  4. The pooling and comparisons across both other EU countries of the International Tobacco Control (ITC) Project and other non-EU countries will be performed to enhance innovative joint research collaborations.


  • WP1. Coordination (WP Leader: ENSP).
  • WP2. Longitudinal Cohort Study on Tobacco Control in the EU: Wave 1 (WP Leader: UW).
  • WP3. Longitudinal Cohort Study on Tobacco Control in the EU: Wave 2 (WP Leader: UOA).
  • WP4. Cross-country analyses of ITC cohorts: EU and non-EU pooled analyses (WP Leader: KCL).
  • WP5. Secondary analyses of the Special Eurobarometer on Tobacco Surveys (WP Leader: UOC).
  • WP6. Assessing e-cigarette product compliance to the TPD (WP Leader: DKFZ).
  • WP7. Maximising impact through communication and dissemination (WP Leader: ERS).


Rajani, N. B., Vlachantoni, I. T., Vardavas, C. I., & Filippidis, F. T. (2017). The association between occupational secondhand smoke exposure and life satisfaction among adults in the European Union. Tobacco Induced Diseases, 15(1), 19. doi:10.1186/s12971-017-0127-x

Filippidis, F. T., Laverty, A. A., & Vardavas, C. I. (2016). Experimentation with e-cigarettes as a smoking cessation aid: a cross-sectional study in 28 European Union member states. BMJ Open, 6(10). doi:10.1136/bmjopen-2016-012084

Laverty, A. A., Vardavas, C. I., & Filippidis, F. T. (2016). Design and marketing features influencing choice of e-cigarettes and tobacco in the EU. European Journal of Public Health, 26(5), 838-841. doi:10.1093/eurpub/ckw109 

 Vardavas, C. (2016). EUREST PLUS - European Regulatory Science on Tobacco: Policy implementation to reduce lung diseases - Proposal (Horizon2020). Tobacco Prevention & Cessation, 2(April Supplement). doi:10.18332/tpc/62406